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hepatocyte growth factor; hepatopoietin-A; scatter factor; SF (HGF, HPTA)

Function: - potent mitogen for mature parenchymal hepatocyte cells - seems to be an hepatotrophic factor - acts as growth factor for a broad spectrum of tissues & cell types - stimulates the formation of focal adhesions. - has no detectable protease activity Structure: - dimer of an alpha chain & a beta chain linked by a disulfide bond - belongs to the peptidase S1 family, plasminogen subfamily - contains 4 kringle domains - contains 1 PAN domain - contains 1 peptidase S1 domain Alternative splicing: named isoforms=6 Pathology: - defects in HGF are the cause of autosomal recessive deafness type 39 Laboratory: - hepatocyte growth factor in serum

Related

hepatocyte growth factor activator (HGFAC) hepatocyte growth factor receptor; HGF receptor; scatter factor receptor; SF receptor; HGF/SF receptor; Met proto-oncogene tyrosine kinase; c-Met (MET)

General

glycoprotein secreted protein

Properties

SIZE: entity length = 728 aa MW = 83 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-31} PAN {37-123} MOTIF: cysteine residue {C70} MODIFICATION: cysteine residue {C96} cysteine residue {C74} MODIFICATION: cysteine residue {C84} cysteine residue {C84} MODIFICATION: cysteine residue {C74} cysteine residue {C96} MODIFICATION: cysteine residue {C70} Kringle 1 {128-206} MOTIF: cysteine residue {C128} MODIFICATION: cysteine residue {C206} cysteine residue {C149} MODIFICATION: cysteine residue {C189} cysteine residue {C177} MODIFICATION: cysteine residue {C201} cysteine residue {C189} MODIFICATION: cysteine residue {C149} cysteine residue {C201} MODIFICATION: cysteine residue {C177} cysteine residue {C206} MODIFICATION: cysteine residue {C128} Kringle 2 {211-288} MOTIF: cysteine residue {C211} MODIFICATION: cysteine residue {C288} cysteine residue {C232} MODIFICATION: cysteine residue {C271} cysteine residue {C260} MODIFICATION: cysteine residue {C283} cysteine residue {C271} MODIFICATION: cysteine residue {C232} cysteine residue {C283} MODIFICATION: cysteine residue {C260} cysteine residue {C288} MODIFICATION: cysteine residue {C211} N-glycosylation site {N294} Kringle 3 {305-383} MOTIF: cysteine residue {C305} MODIFICATION: cysteine residue {C383} cysteine residue {C326} MODIFICATION: cysteine residue {C365} cysteine residue {C354} MODIFICATION: cysteine residue {C377} cysteine residue {C365} MODIFICATION: cysteine residue {C326} cysteine residue {C377} MODIFICATION: cysteine residue {C354} cysteine residue {C383} MODIFICATION: cysteine residue {C305} Kringle 4 {391-469} MOTIF: cysteine residue {C391} MODIFICATION: cysteine residue {C469} N-glycosylation site {N402} cysteine residue {C412} MODIFICATION: cysteine residue {C452} cysteine residue {C440} MODIFICATION: cysteine residue {C464} cysteine residue {C452} MODIFICATION: cysteine residue {C412} cysteine residue {C464} MODIFICATION: cysteine residue {C440} cysteine residue {C469} MODIFICATION: cysteine residue {C391} Thr glycosylation site {T476} cysteine residue {C487} MODIFICATION: cysteine residue {C-INTERCHAIN} S1 domain {495-721} MOTIF: cysteine residue {C519} MODIFICATION: cysteine residue {C535} cysteine residue {C535} MODIFICATION: cysteine residue {C519} N-glycosylation site {N566} cysteine residue {C612} MODIFICATION: cysteine residue {C679} cysteine residue {C642} MODIFICATION: cysteine residue {C658} N-glycosylation site {N653} cysteine residue {C658} MODIFICATION: cysteine residue {C642} cysteine residue {C669} MODIFICATION: cysteine residue {C697} cysteine residue {C679} MODIFICATION: cysteine residue {C612} cysteine residue {C697} MODIFICATION: cysteine residue {C669}

Database Correlations

OMIM correlations UniProt P14210 PFAM correlations Entrez Gene 3082 Kegg hsa:3082

References

  1. UniProt :accession P14210
  2. NIEHS-SNPs http://egp.gs.washington.edu/data/hgf/
  3. Wikipedia; Note: hepatocyte growth factor entry http://en.wikipedia.org/wiki/hepatocyte_growth_factor