hepatitis B virus X-associated protein selections

hepatitis B virus X-associated protein; remodeling & spacing factor 1; Rsf-1; HBV pX-associated protein 8; p325 subunit of RSF chromatin-remodeling complex (RSF1 HBXAP XAP8)

Function: - required for assembly of regular nucleosome arrays by the RSF chromatin remodelling complex - represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain - phosphorylated upon DNA damage, probably by ATM or ATR - interacts with SMARCA5 to form the RSF complex Structure: - contains 1 DDT domain - contains 1 PHD-type Zn⁺² finger Compartment: nucleus Alternative splicing: named isoforms=3 Expression: ubiquitously expressed Pathology: - mutations in gene associated with aggressive ovarian cancer [2] - binds the hepatitis B virus (HBV) pX/HBx protein - facilitates transcription of hepatitis B virus (HBV) genes by the HBV pX transcription activator - in case of infection by HBV, together with pX, represses TNF-alpha induced NF-kappa-B transcription activation

General

nuclear protein phosphoprotein zinc finger protein

Properties

SIZE: entity length = 1441 aa MW = 164 kD COMPARTMENT: cell nucleus MOTIF: DDT {17-84} glutamate-rich region {226-372} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S392} Ser phosphorylation site {S397} Ser phosphorylation site {S473} Thr phosphorylation site {T506} Ser phosphorylation site {S524} Ser phosphorylation site {S540} Ser phosphorylation site {S604} Ser phosphorylation site {S622} Ser phosphorylation site {S629} Ser phosphorylation site {S748} Ser phosphorylation site {S778} Ser phosphorylation site {S782} glutamate-rich region {875-884} MOTIF: glutamate residue (SEVERAL) Zn finger PHD-type NAME: Zn finger PHD-type SITE: 891-941 EFFECTOR-BOUND: Zn+2 coiled coil {942-1012} alanine-rich region {1080-1083} MOTIF: alanine residue (SEVERAL) Ser phosphorylation site {S1096} Ser phosphorylation site {S1098} Ser phosphorylation site {S1105} arginine-rich region {1146-1243} MOTIF: arginine residue (SEVERAL) Ser phosphorylation site {S1221} Ser phosphorylation site {S1223} Ser phosphorylation site {S1226} Ser phosphorylation site {S1277} Thr phosphorylation site {T1278} Tyr phosphorylation site {Y1281} glutamate-rich region {1286-1292} MOTIF: glutamate residue (SEVERAL) Thr phosphorylation site {T1305} Ser phosphorylation site {S1325} Ser phosphorylation site {S1345} Ser phosphorylation site {S1359} Tyr phosphorylation site {Y1363} Ser phosphorylation site {S1364} Ser phosphorylation site {S1375} glutamate-rich region {1419-1424} MOTIF: glutamate residue (SEVERAL)

Database Correlations

OMIM 608522 UniProt Q96T23 Pfam PF00628 Entrez Gene 51773 Kegg hsa:51773

References

UniProt :accession Q96T23
Internal Medicine World Report, Dec 2005 cites le-M Singh, PNAS 2005; 102:14004
Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org//genes/RSF1ID44107ch11q13.html

Component-of

RSF chromatin remodelling complex (remodeling & spacing factor)

Contents