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hepatitis A virus cellular receptor 2 (HAVcr-2, T cell immunoglobulin & mucin domain-containing protein 3, TIMD-3, T cell membrane protein 3, TIM-3, HAVCR2, TIM3, TIMD3)
Function:
1) regulates macrophage activation
2) inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- & alloimmune responses & promotes immunological tolerance
3) role in T-cell homing
4) receptor for LGALS9
Structure:
1) belongs to the immunoglobulin superfamily, TIM family
2) contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment: membrane
Alternative splicing: named isoforms=2
Expression: T-helper type 1 lymphocyte (Th1)-specific
Pathology:
- hepatitis A virus cellular receptor
- genetic variation in HAVCR2 may influence susceptibility to rheumatoid arthritis
General
glycoprotein
virus receptor
Properties
SIZE: MW = 33 kD
entity length = 301 aa
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-21}
immunoglobulin superfamily domain {22-124}
MOTIF: cysteine residue {C38}
MODIFICATION: cysteine residue {C110}
cysteine residue {C110}
MODIFICATION: cysteine residue {C38}
N-glycosylation site {N172}
transmembrane domain {203-223}
Database Correlations
OMIM correlations
UniProt Q8TDQ0
Pfam PF07686
References
UniProt :accession Q8TDQ0