hepatitis A virus cellular receptor 1 (HAVcr-1, T cell immunoglobulin & mucin domain-containing protein 1, TIMD-1, T cell membrane protein 1, TIM-1, TIM, HAVCR1, TIM1, TIMD1)

Function: 1) role in T-helper cell development (putative) 2) receptor for TIMD4 Structure: - belongs to the immunoglobulin superfamily, TIM family - contains 1 Ig-like V-type domain (immunoglobulin-like) Compartment: membrane Expression: - widely expressed, highest levels in kidney & testis - expressed by activated CD4+ T-cells during development of helper T-cells responses Pathology: - cell-surface receptor for hepatitis A virus (HAV) - regulation of asthma & allergic diseases Polymorphism: - HAV seropositivity protects against atopy in individuals with variants Met-Thr-Thr-Val-Pro-157 ins & Met-Thr-Thr-Thr-Val-Pro-157 ins - reduction in HAV seroprevalence diminishes selection for atopy-protective alleles, & perhaps an increase in prevelance of atopy, i.e. asthma, allergic rhinitis & atopic dermatitis. - allelic variation does not affect HAV-infection rates

General

cell surface receptor glycoprotein immunoglobulin superfamily protein

Properties

SIZE: MW = 39 kD entity length = 359 aa COMPARTMENT: plasma membrane MOTIF: signal sequence {1-20} immunoglobulin superfamily domain {21-121} MOTIF: cysteine residue {C36} MODIFICATION: cysteine residue {C105} N-glycosylation site {N65} cysteine residue {C105} MODIFICATION: cysteine residue {C36} threonine-rich region {130-205} MOTIF: threonine residue (SEVERAL) transmembrane domain {291-311}

Database Correlations

OMIM 606518 UniProt Q96D42 Pfam PF07686

References

UniProt :accession Q96D42