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hepatic leukemia factor (HLF)
Function:
- binds DNA specifically as homodimer or heterodimer with other PAR factors
Structure:
- belongs to the bZIP family, PAR subfamily
- contains 1 bZIP domain
Compartment: nucleus (probable)
Expression:
- highly expressed in liver; lower levels in lung & kidney
- accumulates according to a robust circadian rhythm
Pathology:
- chromosomal translocation t(17;19)(q22;p13.3) involving TCF3 with HLF is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL)
General
basic leucine zipper (bZIP) family protein
Properties
SIZE: MW = 33 kD
entity length = 295 aa
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 158-209
MOTIF: proline residue (SEVERAL)
DNA-binding motif
SITE: 231-246
leucine zipper
SITE: 253-274
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM 142385
UniProt Q16534
Pfam PF07716
Entrez Gene 3131
Kegg hsa:3131
References
- UniProt :accession Q16534
- Entrez Gene :accession 3131
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/HLFID47.html