heparin-protamine tolerance test; heparin-protamine titration assay; heparin-protamine neutralization

Unclear how this test is performed. Clinical significance: - when administered alone, protamine sulfate is an anticoagulant - when given to a patient treated with heparin, a stable complex is formed & both heparin & protamine lose activity - the complex forms as a result of the positively charged protamine & the negatively charged heparin - neutralization of heparin occurs within 5 minutes of intravenous protamine sulfate injection

Related

heparin protamine sulfate

References

Protamine sulfate Pharmaceutical Partners of Canada http://ppcdrugs.com/en/products/product_inserts/EN_WebInsert_ProtaminSulf.pdf