Search
heparan sulfate glucosamine 3-O-sulfotransferase 6; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6; 3-OST-6; heparan sulfate 3-O-sulfotransferase 6; h3-OST-6 (HS3ST6)
Function:
- transfers a sulfuryl group to heparan sulfate
- unlike HS3ST1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
Structure: belongs to the sulfotransferase 1 family
Compartment:
- Golgi membrane; single-pass type 2 membrane protein (probable)
Pathology:
- substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor for Herpes simplex virus-1 (HSV-1) & permits its entry.
General
glycoprotein
membrane protein
sulfotransferase
Properties
SIZE: entity length = 342 aa
MW = 37 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {32-49}
Substrate binding {122-128}
Substrate binding {153-156}
Substrate binding {220-221}
N-glycosylation site {N281}
cysteine residue {C288}
MODIFICATION: cysteine residue {C300}
cysteine residue {C300}
MODIFICATION: cysteine residue {C288}
Database Correlations
UniProt Q96QI5
Pfam PF00685
ENZYME 2.8.2.23
References
- UniProt :accession Q96QI5
- GGDB; Note: glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/