heparan-sulfate 6-O-sulfotransferase 3; HS6ST-3 (HS6ST3)

Function: - 6-O-sulfation enzyme - catalyzes transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparansulfate 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate Structure: belongs to the sulfotransferase 6 family Compartment: membrane

General

glycoprotein membrane protein sulfotransferase

Properties

SIZE: MW = 55 kD entity length = 471 aa COMPARTMENT: cellular membrane MOTIF: transmembrane domain {5-27} N-glycosylation site {N117} N-glycosylation site {N128} binding site SITE: 155-161 FOR-BINDING-OF: 5'-PHOSPHOSULFATE N-glycosylation site {N231} 3'-phosphate binding {245-253} N-glycosylation site {N324} N-glycosylation site {N329} N-glycosylation site {N380}

Database Correlations

UniProt Q8IZP7 Pfam PF06765

References

UniProt :accession Q8IZP7