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heparan-sulfate 6-O-sulfotransferase 2 (HS6ST-2, HS6ST2)
Function:
- 6-O-sulfation enzyme
- catalyzes transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate
3'-phosphoadenylyl sulfate + [heparansulfate]-glucosamine adenosine 3',5'-bisphosphate + [heparansulfate]-glucosamine 6-sulfate
Structure: belongs to the sulfotransferase 6 family
Compartment: membrane
Alternative splicing: named isoforms=3
General
glycoprotein
membrane protein
sulfotransferase
Properties
SIZE: MW = 69 kD
entity length = 605 aa
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {5-27}
N-glycosylation site {N209}
binding site
SITE: 236-242
FOR-BINDING-OF: 5'-PHOSPHOSULFATE
3'-phosphate binding {325-333}
N-glycosylation site {N404}
N-glycosylation site {N460}
N-glycosylation site {N544}
N-glycosylation site {N556}
N-glycosylation site {N564}
N-glycosylation site {N589}
N-glycosylation site {N592}
Database Correlations
UniProt Q96MM7
Pfam PF06765
References
UniProt :accession Q96MM7