heparan-sulfate 6-O-sulfotransferase 1; HS6ST-1 (HS6ST1, HS6ST)

Function: - catalyzes transfer of sulfate from PAPS to position 6 of N-sulfoglucosamine residue (GlcNS) of heparan sulfate Structure: - N-glycosylated - belongs to the sulfotransferase 6 family Compartment: - membrane - single-pass type 2 membrane protein (putative) Expression: expressed in fetal brain

General

glycoprotein sulfotransferase

Properties

SIZE: entity length = 411 aa MW = 48 kD COMPARTMENT: cellular membrane MOTIF: arginine-rich region {2-5} MOTIF: arginine residue (SEVERAL) transmembrane domain {18-37} binding site SITE: 96-102 FOR-BINDING-OF: 5'-PHOSPHOSULFATE 3'-phosphate binding {185-193} N-glycosylation site {N264} N-glycosylation site {N320} coiled coil {352-387}

Database Correlations

OMIM 604846 UniProt O60243 Pfam PF03567 Entrez Gene 9394 Kegg hsa:9394

References

UniProt :accession O60243