heparan sulfate 2-O-sulfotransferase 1; 2-O-sulfotransferase (2OST, HS2ST1, HS2ST, KIAA0448)

Function: 1) catalyzes transfer of sulfate to the C2-position of hexuronic acid residues within the maturing heparan sulfate 2) mediates 2-O-sulfation of both L-iduronyl & D-glucuronyl residues 3) interacts with C5-epimerase GLCE Structure: - N-glycosylated Compartment: Golgi membrane Alternative splicing: named isoforms=3

General

glycoprotein membrane protein sulfotransferase

Properties

SIZE: MW = 42 kD entity length = 356 aa COMPARTMENT: golgi MOTIF: transmembrane domain {12-28} N-glycosylation site {N108} N-glycosylation site {N127}

Database Correlations

OMIM 604844 UniProt Q7LGA3 Pfam PF05040

References

UniProt :accession Q7LGA3