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heparanase-2 (Hpa2, HPSE2, HPA2)
Function:
- endoglycosidase
- cell surface & extracellular matrix-degrading enzyme
- cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains & core proteoglycans
- implicated in the extravasation of leukocytes & tumor cells
- contribution to angiogenesis
Structure: belongs to the glycosyl hydrolase 79 family
Compartment: membrane, peripheral membrane
Alternative splicing: named isoforms=4
Expression:
- widely expressed
- highest expression in brain, mammary gland, prostate, small intestine, testis & uterus
- found both in normal & cancer tissues
Pathology:
- contribution to metastasis & angiogenesis
- considered to be a potential target for anti-cancer therapies
Related
heparanase (heparanase-1; Hpa1; endo-glucoronidase; P1-A-1 platelet antigen [Contains: Heparanase 8 kD subunit; Heparanase 50 kD subunit], HPSE, HEP, HPA, HPA1, HPR1, HPSE1, HSE1)
General
glycosidase (glycoside hydrolase)
Properties
SIZE: MW = 67 kD
entity length = 592 aa
MOTIF: glutamate residue {E262}
Database Correlations
UniProt Q8WWQ2
Pfam PF03662
References
UniProt :accession Q8WWQ2