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hemoglobin-variant
Globin mutations may affect hemoglobin stability or oxygen affinity. Increased oxygen affinity:
1) low venous blood P50*
2) erythrocytosis Decreased oxygen affinity:
1) high venous blood P50*
2) diminished erythropoietin levels
3) physiological anemia
* pO2 at 50% hemoglobin saturation with oxygen
Laboratory: (diagnosis)
- hemoglobin electrophoresis
Related
hemoglobin electrophoresis
unstable hemoglobin
Specific
hemoglobin A2'
hemoglobin Abruzzo
hemoglobin Barts
hemoglobin Bethesda
hemoglobin C
hemoglobin Chesapeake
hemoglobin Constant Spring
hemoglobin D
hemoglobin Denver
hemoglobin E
hemoglobin G
hemoglobin H
hemoglobin Hasharon
hemoglobin Hope
hemoglobin J
hemoglobin Kansas
hemoglobin Kempsey
hemoglobin Koln
hemoglobin Lepore
hemoglobin M
hemoglobin M Boston
hemoglobin Malmo
hemoglobin N
hemoglobin O
hemoglobin Rainer
hemoglobin S
hemoglobin Yakima
hemoglobin Yoshizuka
hemoglobin Ypsilanti
hemoglobin Zurich
General
hemoglobin
Properties
COMPARTMENT: cytoplasm
CELL: erythrocyte
SUBUNITS: hemoglobin alpha chain
:QUANTITY 2
hemoglobin beta chain
:QUANTITY 2
References
- Clinical Diagnosis & Management by Laboratory Methods,
J.B. Henry (ed), W.B. Saunders Co., Philadelphia,
PA. 1991, pg 650
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
Components
hemoglobin alpha chain (alpha globin, HBA1, HBA2)
hemoglobin beta chain (beta globin, HBB)
hemoglobin delta chain (delta-globin, HBD)
hemoglobin gamma chain