hemogen (hemopoietic gene protein, negative differentiation regulator protein, erythroid differentiation-associated gene protein, EDAG-1, HEMGN, EDAG, NDR, PRO1037, PRO1620)

Function: - regulates proliferation & differentiation of hematopoietic cells - overexpression blocks TPA-induced megakaryocytic differentiation in the K562 cells - may prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) Compartment: nucleus Expression: - expressed in hematopoietic precursor cells (at protein level) - detected in CD34+ & K562 leukemia cell line - expressed in bone marrow, testis, thymus - expressed in fetal liver, kidney & brain - down-regulated during megakaryocytic differentiation of K562 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) (at protein level) - up-regulated in normal PBMCs by mitogens Pathology: - expressed in thymus & thyroid tumors, non-Hodgkins lymphoma, leukemia cell lines, peripheral blood mononuclear cells & bone marrow mononuclear cells (BMMCs) of patients with leukemia

Properties

SIZE: MW = 55 kD entity length = 484 aa COMPARTMENT: cell nucleus MOTIF: nuclear translocation signal {7-87}

References

UniProt :accession Q9BXL5