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hemicentin-2 (HMCN2)
Structure:
- contains 5 EGF-like domains
- contains 42 Ig-like C2-type domains
- contains 1 nidogen G2 beta-barrel domain
- contains 1 VWFA domain
Compartment:
- secreted, extracellular space, extracellular matrix (putative)
Alternative splicing: named isoforms=3
General
glycoprotein
secreted protein
Properties
SIZE: entity length = 5065 aa
MW = 543 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-23}
VWFA domain {36-210}
N-glycosylation site {N329}
N-glycosylation site {N346}
N-glycosylation site {N379}
N-glycosylation site {N478}
immunoglobulin superfamily domain {518-603}
MOTIF: N-glycosylation site {N525}
cysteine residue {C538}
MODIFICATION: cysteine residue {C587}
N-glycosylation site {N547}
cysteine residue {C587}
MODIFICATION: cysteine residue {C538}
immunoglobulin superfamily domain {608-691}
MOTIF: cysteine residue {C629}
MODIFICATION: cysteine residue {C677}
N-glycosylation site {N674}
cysteine residue {C677}
MODIFICATION: cysteine residue {C629}
immunoglobulin superfamily domain {698-781}
MOTIF: cysteine residue {C719}
MODIFICATION: cysteine residue {C765}
cysteine residue {C765}
MODIFICATION: cysteine residue {C719}
immunoglobulin superfamily domain {786-880}
MOTIF: cysteine residue {C807}
MODIFICATION: cysteine residue {C862}
cysteine residue {C862}
MODIFICATION: cysteine residue {C807}
immunoglobulin superfamily domain {885-971}
MOTIF: cysteine residue {C906}
MODIFICATION: cysteine residue {C955}
cysteine residue {C955}
MODIFICATION: cysteine residue {C906}
immunoglobulin superfamily domain {976-1062}
MOTIF: cysteine residue {C997}
MODIFICATION: cysteine residue {C1046}
N-glycosylation site {N1024}
immunoglobulin superfamily domain {1039-1115}
MOTIF: cysteine residue {C1046}
MODIFICATION: cysteine residue {C997}
immunoglobulin superfamily domain {1120-1200}
MOTIF: cysteine residue {C1141}
MODIFICATION: cysteine residue {C1184}
cysteine residue {C1184}
MODIFICATION: cysteine residue {C1141}
immunoglobulin superfamily domain {1207-1294}
MOTIF: N-glycosylation site {N1223}
cysteine residue {C1228}
MODIFICATION: cysteine residue {C1278}
cysteine residue {C1278}
MODIFICATION: cysteine residue {C1228}
immunoglobulin superfamily domain {1299-1400}
MOTIF: N-glycosylation site {N1309}
cysteine residue {C1322}
MODIFICATION: cysteine residue {C1386}
cysteine residue {C1386}
MODIFICATION: cysteine residue {C1322}
immunoglobulin superfamily domain {1407-1496}
MOTIF: cysteine residue {C1430}
MODIFICATION: cysteine residue {C1480}
cysteine residue {C1480}
MODIFICATION: cysteine residue {C1430}
immunoglobulin superfamily domain {1501-1589}
MOTIF: N-glycosylation site {N1507}
cysteine residue {C1524}
MODIFICATION: cysteine residue {C1573}
N-glycosylation site {N1533}
cysteine residue {C1573}
MODIFICATION: cysteine residue {C1524}
immunoglobulin superfamily domain {1594-1685}
MOTIF: cysteine residue {C1618}
MODIFICATION: cysteine residue {C1667}
N-glycosylation site {N1641}
cysteine residue {C1667}
MODIFICATION: cysteine residue {C1618}
immunoglobulin superfamily domain {1688-1776}
MOTIF: cysteine residue {C1711}
MODIFICATION: cysteine residue {C1760}
cysteine residue {C1760}
MODIFICATION: cysteine residue {C1711}
immunoglobulin superfamily domain {1783-1879}
MOTIF: cysteine residue {C1807}
MODIFICATION: cysteine residue {C1865}
cysteine residue {C1865}
MODIFICATION: cysteine residue {C1807}
immunoglobulin superfamily domain {1886-1974}
MOTIF: N-glycosylation site {N1900}
cysteine residue {C1907}
MODIFICATION: cysteine residue {C1956}
cysteine residue {C1956}
MODIFICATION: cysteine residue {C1907}
immunoglobulin superfamily domain {1977-2066}
MOTIF: cysteine residue {C1999}
MODIFICATION: cysteine residue {C2050}
N-glycosylation site {N2000}
cysteine residue {C2050}
MODIFICATION: cysteine residue {C1999}
immunoglobulin superfamily domain {2071-2157}
MOTIF: N-glycosylation site {N2079}
N-glycosylation site {N2085}
cysteine residue {C2092}
MODIFICATION: cysteine residue {C2141}
cysteine residue {C2141}
MODIFICATION: cysteine residue {C2092}
immunoglobulin superfamily domain {2162-2253}
MOTIF: cysteine residue {C2184}
MODIFICATION: cysteine residue {C2235}
cysteine residue {C2235}
MODIFICATION: cysteine residue {C2184}
N-glycosylation site {N2243}
immunoglobulin superfamily domain {2256-2345}
MOTIF: cysteine residue {C2280}
MODIFICATION: cysteine residue {C2329}
N-glycosylation site {N2281}
cysteine residue {C2329}
MODIFICATION: cysteine residue {C2280}
immunoglobulin superfamily domain {2350-2439}
MOTIF: N-glycosylation site {N2361}
cysteine residue {C2374}
MODIFICATION: cysteine residue {C2423}
cysteine residue {C2423}
MODIFICATION: cysteine residue {C2374}
N-glycosylation site {N2435}
immunoglobulin superfamily domain {2444-2532}
MOTIF: cysteine residue {C2467}
MODIFICATION: cysteine residue {C2516}
N-glycosylation site {N2468}
N-glycosylation site {N2507}
cysteine residue {C2516}
MODIFICATION: cysteine residue {C2467}
immunoglobulin superfamily domain {2537-2628}
MOTIF: cysteine residue {C2563}
MODIFICATION: cysteine residue {C2612}
N-glycosylation site {N2572}
cysteine residue {C2612}
MODIFICATION: cysteine residue {C2563}
immunoglobulin superfamily domain {2633-2724}
MOTIF: N-glycosylation site {N2654}
cysteine residue {C2661}
MODIFICATION: cysteine residue {C2710}
cysteine residue {C2710}
MODIFICATION: cysteine residue {C2661}
immunoglobulin superfamily domain {2731-2837}
MOTIF: cysteine residue {C2772}
MODIFICATION: cysteine residue {C2821}
cysteine residue {C2821}
MODIFICATION: cysteine residue {C2772}
immunoglobulin superfamily domain {2841-2930}
MOTIF: N-glycosylation site {N2858}
cysteine residue {C2867}
MODIFICATION: cysteine residue {C2916}
cysteine residue {C2916}
MODIFICATION: cysteine residue {C2867}
immunoglobulin superfamily domain {2937-3024}
MOTIF: N-glycosylation site {N2952}
cysteine residue {C2959}
MODIFICATION: cysteine residue {C3008}
cysteine residue {C3008}
MODIFICATION: cysteine residue {C2959}
immunoglobulin superfamily domain {3029-3119}
MOTIF: cysteine residue {C3054}
MODIFICATION: cysteine residue {C3103}
cysteine residue {C3103}
MODIFICATION: cysteine residue {C3054}
immunoglobulin superfamily domain {3123-3211}
MOTIF: cysteine residue {C3146}
MODIFICATION: cysteine residue {C3195}
cysteine residue {C3195}
MODIFICATION: cysteine residue {C3146}
immunoglobulin superfamily domain {3216-3306}
MOTIF: cysteine residue {C3239}
MODIFICATION: cysteine residue {C3290}
cysteine residue {C3290}
MODIFICATION: cysteine residue {C3239}
immunoglobulin superfamily domain {3311-3398}
MOTIF: cysteine residue {C3335}
MODIFICATION: cysteine residue {C3384}
cysteine residue {C3384}
MODIFICATION: cysteine residue {C3335}
N-glycosylation site {N3396}
immunoglobulin superfamily domain {3404-3489}
MOTIF: cysteine residue {C3428}
MODIFICATION: cysteine residue {C3473}
cysteine residue {C3473}
MODIFICATION: cysteine residue {C3428}
immunoglobulin superfamily domain {3494-3575}
MOTIF: cysteine residue {C3517}
MODIFICATION: cysteine residue {C3559}
N-glycosylation site {N3526}
N-glycosylation site {N3541}
cysteine residue {C3559}
MODIFICATION: cysteine residue {C3517}
immunoglobulin superfamily domain {3580-3668}
MOTIF: cysteine residue {C3603}
MODIFICATION: cysteine residue {C3652}
cysteine residue {C3652}
MODIFICATION: cysteine residue {C3603}
immunoglobulin superfamily domain {3673-3759}
MOTIF: N-glycosylation site {N3683}
N-glycosylation site {N3687}
cysteine residue {C3694}
MODIFICATION: cysteine residue {C3743}
cysteine residue {C3743}
MODIFICATION: cysteine residue {C3694}
immunoglobulin superfamily domain {3764-3854}
MOTIF: N-glycosylation site {N3772}
cysteine residue {C3785}
MODIFICATION: cysteine residue {C3836}
cysteine residue {C3836}
MODIFICATION: cysteine residue {C3785}
immunoglobulin superfamily domain {3857-3943}
MOTIF: cysteine residue {C3878}
MODIFICATION: cysteine residue {C3927}
cysteine residue {C3927}
MODIFICATION: cysteine residue {C3878}
immunoglobulin superfamily domain {3948-4033}
MOTIF: cysteine residue {C3969}
MODIFICATION: cysteine residue {C4017}
cysteine residue {C4017}
MODIFICATION: cysteine residue {C3969}
immunoglobulin superfamily domain {4037-4124}
MOTIF: cysteine residue {C4059}
MODIFICATION: cysteine residue {C4108}
N-glycosylation site {N4068}
cysteine residue {C4108}
MODIFICATION: cysteine residue {C4059}
immunoglobulin superfamily domain {4129-4210}
MOTIF: cysteine residue {C4150}
MODIFICATION: cysteine residue {C4197}
cysteine residue {C4197}
MODIFICATION: cysteine residue {C4150}
immunoglobulin superfamily domain {4218-4301}
MOTIF: cysteine residue {C4240}
MODIFICATION: cysteine residue {C4288}
N-glycosylation site {N4270}
cysteine residue {C4288}
MODIFICATION: cysteine residue {C4240}
immunoglobulin superfamily domain {4309-4394}
MOTIF: cysteine residue {C4330}
MODIFICATION: cysteine residue {C4378}
cysteine residue {C4378}
MODIFICATION: cysteine residue {C4330}
Nidogen G2 beta-barrel {4398-4620}
MOTIF: N-glycosylation site {N4421}
N-glycosylation site {N4567}
EGF domain {4634-4674}
MOTIF: cysteine residue {C4638}
MODIFICATION: cysteine residue {C4649}
cysteine residue {C4645}
MODIFICATION: cysteine residue {C4658}
cysteine residue {C4649}
MODIFICATION: cysteine residue {C4638}
cysteine residue {C4658}
MODIFICATION: cysteine residue {C4645}
cysteine residue {C4660}
MODIFICATION: cysteine residue {C4673}
cysteine residue {C4673}
MODIFICATION: cysteine residue {C4660}
EGF domain {4675-4718}
MOTIF: cysteine residue {C4679}
MODIFICATION: cysteine residue {C4692}
cysteine residue {C4686}
MODIFICATION: cysteine residue {C4701}
cysteine residue {C4692}
MODIFICATION: cysteine residue {C4679}
cysteine residue {C4701}
MODIFICATION: cysteine residue {C4686}
cysteine residue {C4705}
MODIFICATION: cysteine residue {C4717}
cysteine residue {C4717}
MODIFICATION: cysteine residue {C4705}
EGF domain {4719-4757}
MOTIF: cysteine residue {C4723}
MODIFICATION: cysteine residue {C4736}
cysteine residue {C4730}
MODIFICATION: cysteine residue {C4745}
cysteine residue {C4736}
MODIFICATION: cysteine residue {C4723}
cysteine residue {C4745}
MODIFICATION: cysteine residue {C4730}
EGF domain {4762-4802}
MOTIF: cysteine residue {C4766}
MODIFICATION: cysteine residue {C4777}
cysteine residue {C4773}
MODIFICATION: cysteine residue {C4786}
cysteine residue {C4777}
MODIFICATION: cysteine residue {C4766}
cysteine residue {C4786}
MODIFICATION: cysteine residue {C4773}
cysteine residue {C4788}
MODIFICATION: cysteine residue {C4801}
cysteine residue {C4801}
MODIFICATION: cysteine residue {C4788}
N-glycosylation site {N4810}
EGF domain {4869-4908}
MOTIF: cysteine residue {C4873}
MODIFICATION: cysteine residue {C4883}
cysteine residue {C4879}
MODIFICATION: cysteine residue {C4892}
cysteine residue {C4883}
MODIFICATION: cysteine residue {C4873}
cysteine residue {C4892}
MODIFICATION: cysteine residue {C4879}
cysteine residue {C4894}
MODIFICATION: cysteine residue {C4907}
cysteine residue {C4907}
MODIFICATION: cysteine residue {C4894}
N-glycosylation site {N5000}
Database Correlations
UniProt Q8NDA2
PFAM correlations
Entrez Gene 256158
References
UniProt :accession Q8NDA2