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heme oxygenase-2 (HMOX2, HO-2)
Function:
- in association with cyt P450 reductase & bilirubin reductase, cleaves heme to form bilirubin, CO & Fe+2
- electrons donated by cyt P450 reductase
- biliverdin reductase rapidly reduces biliverdin to bilirubin
- could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter
heme oxygenase
cyt P450 reductase
heme[Fe+2] + O2 ------------------> biliverdin + CO + Fe+2
+ NADPH + H+ + NADP+ + H2O
biliverdin reductase
biliverdin ------------------> bilirubin + NADP+
+ NADPH + H+
Structure:
- belongs to the heme oxygenase family
- contains 2 HRM (heme regulatory motif) repeats
Compartment: microsome
Expression:
- constitutively expressed form of heme oxygenase
- major form of heme oxygenase found in brain
General
heme oxygenase
Properties
COMPARTMENT: cellular compartment
CELL: neuron
WITHIN: brain
MOTIF: active site
Database Correlations
OMIM 141251
UniProt P30519
Pfam PF01126
ENZYME 1.14.99.3
References
- Snyder SH.
Nitric oxide: first in a new class of neurotransmitters.
Science. 1992 Jul 24;257(5069):494-6. Review.
PMID: 1353273
- Smith MA, Kutty RK, Richey PL, Yan SD, Stern D, Chader GJ,
Wiggert B, Petersen RB, Perry G.
Heme oxygenase-1 is associated with the neurofibrillary
pathology of Alzheimer's disease.
Am J Pathol. 1994 Jul;145(1):42-7.
PMID: 8030754
- Sedlak TW, Snyder SH.
Messenger molecules & cell death: therapeutic implications.
JAMA. 2006 Jan 4;295(1):81-9.
PMID: 16391220
- UniProt :accession P30519
Component-of
multienzyme complex