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Helix-loop-helix protein 2; HEN-2; class A basic helix-loop-helix protein 34; bHLHa34; Nescient helix loop helix 2; NSCL-2 (NHLH2, BHLHA34, HEN2, KIAA0490)
Function:
- may serve as DNA-binding protein
- may be involved in control of cell-type determination, possibly within the developing nervous system
- efficient DNA binding requires dimerization with another bHLH protein
Structure: contains 1 basic helix-loop-helix (bHLH) domain
Compartment: nucleus (putative)
General
basic helix loop helix (bHLH) family transcription factor
Properties
SIZE: entity length = 135 aa
MW = 15 kD
COMPARTMENT: cell nucleus
MOTIF: arginine-rich region {69-73}
MOTIF: arginine residue (SEVERAL)
DNA-binding motif
SITE: 77-89
helix-loop-helix
NAME: helix-loop-helix
SITE: 90-130
FOR-BINDING-VIA: helix-loop-helix
Database Correlations
OMIM 162361
UniProt Q02577
Pfam PF00010
Kegg hsa:4808
References
UniProt :accession Q02577