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Helix-loop-helix protein 1; HEN-1; class A basic helix-loop-helix protein 35; bHLHa35; Nescient helix loop helix 1; NSCL-1 (NHLH1, BHLHA35, HEN1)
Function:
- may serve as DNA-binding protein
- may be involved in control of cell-type determination, possibly within the developing nervous system
- efficient DNA binding requires dimerization with another bHLH protein
Structure: contains 1 basic helix-loop-helix (bHLH) domain
Compartment: nucleus (putative)
General
basic helix loop helix (bHLH) family transcription factor
Properties
SIZE: entity length = 133 aa
MW = 15 kD
COMPARTMENT: cell nucleus
MOTIF: arginine-rich region {66-71}
MOTIF: arginine residue (SEVERAL)
DNA-binding motif
SITE: 75-87
helix-loop-helix
NAME: helix-loop-helix
SITE: 88-128
FOR-BINDING-VIA: helix-loop-helix
Database Correlations
OMIM 162360
UniProt Q02575
Pfam PF00010
Entrez Gene 4807
Kegg hsa:4807
References
UniProt :accession Q02575