Search
A-kinase anchor protein 8-like; AKAP8-like protein; helicase A-binding protein 95; HAP95; homologous to AKAP95 protein; HA95; neighbor of A-kinase-anchoring protein 95; neighbor of AKAP95 (AKAP8L, NAKAP, NAKAP95, HRIHFB2018)
Function:
- may play a role in constitutive transport element (CTE)-mediated gene expression
- may be involved in nuclear envelope breakdown & chromatin condensation
- may regulate initiation phase of DNA replication when associated with TMPO-beta
- phosphorylated on Ser or Thr possibly by PKA
- interacts with PRPF40A (putative)
- binds to the C-terminal of RNA helicase A & to TMPO-beta
- interacts with RNF43
Structure: belongs to the AKAP95 family
Compartment:
- nucleus matrix, cytoplasm
- colocalizes with PRPF40A in the nuclear matrix (putative)
- nuclear at steady state but shuttles between the nucleus & cytoplasm
- associated with the nuclear matrix
Expression:
- expressed in the cerebral cortex (at protein level)
General
nuclear protein
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 646 aa
MW = 72 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: nuclear translocation signal {274-279}
Ser phosphorylation site {S283}
Thr phosphorylation site {T292}
Thr phosphorylation site {T294}
Ser phosphorylation site {S297}
Ser phosphorylation site {S300}
Ser phosphorylation site {S302}
Thr phosphorylation site {T308}
nuclear translocation signal {362-364}
Zinc finger
NAME: Zinc finger
SITE: 389-413
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 482-507
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S552}
proline-rich region
SITE: 589-597
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 602-608
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 609475
UniProt Q9ULX6
Pfam PF04988
Entrez Gene 26993
Kegg hsa:26993
References
UniProt :accession Q9ULX6