Helicase ARIP4 (androgen receptor-interacting protein 4, RAD54-like protein 2, RAD54L2, ARIP4, KIAA0809)

Function: - DNA helicase - modulates androgen receptor (AR)-dependent transactivation (promoter-dependent) - not able to remodel mononucleosomes in vitro (putative) - interacts with AR via its N-terminus - interacts with DYRK1A - binds DNA & mononucleosomes, but does not seem to form large multiprotein complexes (putative) - enzyme activity is enhanced by dsDNA (double-stranded DNA) & ssDNA (single-stranded DNA) (putative) - sumoylated (putative) - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to be important for the association with nuclear receptors - belongs to the SNF2/RAD54 helicase family - contains 1 helicase ATP-binding domain - contains 1 helicase C-terminal domain Compartment: - nucleus (putative) - localizes in speckle-like nuclear compartments (putative)

General

helicase (DNA unwinding protein, DNA untwisting protein) nuclear protein phosphoprotein receptor

Properties

SIZE: entity length = 1467 aa MW = 163 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S187} Ser phosphorylation site {S188} Ser phosphorylation site {S189} Ser phosphorylation site {S191} helicase NAME: helicase SITE: 292-512 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 305-312 DEAD/H box NAME: DEAD/H box SITE: 463-466 LXXLL motif 1 {551-555} Helicase C-terminal {728-896} Ser phosphorylation site {S1138} Ser phosphorylation site {S1169} Ser phosphorylation site {S1172} LXXLL motif 2 {1329-1333}

Database Correlations

UniProt Q9Y4B4 PFAM correlations

References

UniProt :accession Q9Y4B4