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hedgehog interacting protein (HHIP, UNQ5825/PRO1964)
Function:
1) modulates hedgehog signaling in brain & lung
2) interacts with all 3 hedgehog family members: SHH, IHH, DHH
Compartment: cell membrane; peripheral membrane, secreted
Alternative splicing: named isoforms=2
Expression:
- widely expressed in fetal & adult tissues
- highest expression in adult heart, liver, pancreas, fetal kidney
General
glycoprotein
membrane protein
Properties
SIZE: MW = 79 kD
entity length = 700 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-17}
arginine-rich region {35-54}
MOTIF: arginine residue (SEVERAL)
N-glycosylation site {N99-N459} (4)
EGF domain {607-634} (2)
MOTIF: cysteine residue {C608}
MODIFICATION: cysteine residue {C623}
cysteine residue {C612}
MODIFICATION: cysteine residue {C624}
cysteine residue {C623}
MODIFICATION: cysteine residue {C608}
cysteine residue {C624}
MODIFICATION: cysteine residue {C612}
cysteine residue {C625}
MODIFICATION: cysteine residue {C634}
cysteine residue {C634}
MODIFICATION: cysteine residue {C625}
Database Correlations
OMIM 606178
UniProt Q96QV1
Pfam PF07974
Entrez Gene 64399
References
- Entrez Gene :accession 64399
- UniProt :accession Q96QV1