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hedgehog family protein

Homologs of hedgehog, a secreted protein involved in establishing cell fate at several points in Drosophila development. Function: - role in cell cycle progression - hedgehog targets include wnt family proteins (Drosophila wingless) & TGF-beta family proteins (Drosophila decapentaplegic) [1] - hedgehog signalling promotes transcription of cyclin E & cyclin D during Drosophila development [2] - cilia may play a role in hedgehog signalling [3] Pathology: - disruption of hedgehog signalling is associated with congenital anomalies of the CNS & other organ systems - activating mutations can result in some skin cancers, including basal cell carcinoma - activation of the hedgehog signalling pathway has been associated with tumorigenesis [4] - tumor cells may induce hedgehog signalling in noncancerous stromal cells that surround the tumor [4] Pharmacology: - glasdegib (Daurismo) an inhibitor of hedgehog signaling is used to treat acute myeloid leukemia

Related

hedgehog interacting protein (HHIP, UNQ5825/PRO1964) skinny hedgehog protein

Specific

desert hedgehog protein; DHH; HHG-3; contains: desert hedgehog protein N-product, desert hedgehog protein C-product (DHH) indian hedgehog protein; IHH; HHG-2; contains: indian hedgehog protein N-product, indian hedgehog protein C-product (IHH) Sonic hedgehog protein; SHH; HHG-1; contains: sonic hedgehog protein N-product, sonic hedgehog protein C-product (SHH)

General

secreted protein

Figures/Diagrams

hedgehog-gli pathway

Properties

COMPARTMENT: extracellular compartment

References

  1. Bale AE. Hedgehog signaling and human disease. Annu Rev Genomics Hum Genet. 2002;3:47-65. Epub 2002 Apr 15. Review. PMID: 12142354
  2. Duman-Scheel M, Weng L, Xin S, Du W. Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature. 2002 May 16;417(6886):299-304. PMID: 12015606
  3. Marigo V et al. Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog. Genomics. 1995 Jul 1;28(1):44-51. PMID: 7590746
  4. Yauch RL et al. A paracrine requirement for hedgehog signalling in cancer. Nature 2008 Sep 18; 455:406. PMID: 18754008
  5. UniProt :accession Q9UG01