heat shock transcription factor-2; heat shock factor protein-2 (HSTF2, HSF2)

Function: - DNA-binding protein that specifically binds heat shock promoter elements (HSE) & activates transcription - in higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked - DNA-binding homotrimer in stressed or heat shocked cells, otherwise found as a homodimer Structure: belongs to the HSF family Compartment: - cytoplasm, nucleus - cytoplasmic during normal growth & moves to the nucleus upon activation

General

heat shock factor phosphoprotein

Properties

CONFIGURATION: trimer SIZE: entity length = 536 aa MW = 60 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: DNA-binding motif SITE: 7-112 nuclear translocation signal {108-122} HR-A/B {119-192} MOTIF: glutamine-rich region {170-173} MOTIF: glutamine residue (SEVERAL) nuclear translocation signal {195-210} HR-C {360-385}

Database Correlations

OMIM correlations UniProt Q03933 PFAM correlations Kegg hsa:3298

References

UniProt :accession Q03933