heat shock factor-binding protein 1; heat shock factor-1 binding protein; nasopharyngeal carcinoma-associated antigen 13; NPC-A-13 (HSBP1, HSF1BP)

Function: - negative regulator of the heat shock response - negatively affects HSF1 DNA-binding activity - may have a role in suppressing activation of the stress response during the aging process - associates with heptad repeats of HSF1 trimers & probably also HSF1 monomers, & with HSP70 - association with HSF1 trimers & HSP70 coincides with attenuation of heat shock response & the conversion of HSF1 trimer to monomer Structure: belongs to the HSBP1 family Compartment: nucleus

General

heat shock protein nuclear protein

Properties

SIZE: entity length = 76 aa MW = 9 kD COMPARTMENT: cell nucleus

Database Correlations

OMIM 604553 UniProt O75506 Pfam PF06825 Entrez Gene 3281 Kegg hsa:3281

References

UniProt :accession O75506