HC motif

The sequence HCXAGXXR is the minimal active site sequence for a large class of tyrosine-specific phosphatases. The conserved cysteine is thought to function as a phosphothiol intermediate.

Properties

MISC-INFO: consensus

References

- Rohan PJ, Davis P, Moskaluk CA, Kearns M, Krutzsch H, Siebenlist U, Kelly K. PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. Science. 1993 Mar 19;259(5102):1763-6. PMID: 7681221