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heparin-binding EGF-like growth factor; heparin-binding protein; HB-EGF; HBEGF; diphtheria toxin receptor; DT-R (HBEGF, DTR, DTS, HEGFL)
Function:
- may be involved in macrophage-mediated cellular proliferation
- mitogenic for fibroblasts & smooth muscle but not endothelial cells
- it is able to bind EGF receptors with higher affinity than EGF itself & is a far more potent mitogenfor smooth muscle cells than EGF
- inducer of increased vascular permeability
- acts as a diphtheria toxin receptor
Structure: contains 1 EGF-like domain
Compartment:
- heparin-binding EGF-like growth factor:
- secreted, extracellular space
- mature HB-EGF is released into the extracellular space & probably binds to a receptor
- proheparin-binding EGF-like growth factor:
- cell membrane; single-pass type 1 membrane protein
Laboratory:
- heparin-binding protein in CSF is a marker for bacterial meningitis Expession:
- released from activated neutrophils in severe sepsis
Related
heparin-binding protein in CSF
General
glycoprotein
growth factor
membrane protein
secreted peptide
Properties
SIZE: entity length = 208 aa
MW = 23 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-19}
Thr glycosylation site {T75}
Thr glycosylation site {T85}
EGF domain {104-144}
MOTIF: cysteine residue {C108}
MODIFICATION: cysteine residue {C121}
cysteine residue {C116}
MODIFICATION: cysteine residue {C132}
cysteine residue {C121}
MODIFICATION: cysteine residue {C108}
cysteine residue {C132}
MODIFICATION: cysteine residue {C116}
cysteine residue {C134}
MODIFICATION: cysteine residue {C143}
glutamate residue {141}
cysteine residue {C143}
MODIFICATION: cysteine residue {C134}
transmembrane domain {161-184}
SECRETED-BY: macrophage
smooth muscle
Database Correlations
OMIM 126150
UniProt Q99075
Entrez Gene 1839
Kegg hsa:1839
References
- UniProt :accession Q99075
- NIEHS-SNPs
http://egp.gs.washington.edu/data/dtr/
- Ross R
The pathogenesis of atherosclerosis
Nature 362:801 1993
PMID: 8479518