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HBO1 complex
Function:
- histone H4-specific acetyltransferase activity
- reduced activity toward histone H3
- responsible for the bulk of histone H4 acetylation in vivo
- through chromatin acetylation, may function in DNA replication
Structure:
- subunits include: ING4 or ING5, KAT7/HBO1, MEAF6, & one of PHF15, PHF16 or PHF17
General
molecular complex
Properties
SUBUNITS: inhibitor of growth protein 4
COMPARTMENT: cell nucleus
MOTIF: coiled coil {25-118}
Ser phosphorylation site {S150}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 196-245
EFFECTOR-BOUND: Zn+2
MOTIF: binding site
SITE: 198-198
FOR-BINDING-OF: Histone H3K4me3
binding site
SITE: 209-209
FOR-BINDING-OF: Histone H3K4me3
binding site
SITE: 213-213
FOR-BINDING-OF: Histone H3K4me3
binding site
SITE: 221-221
FOR-BINDING-OF: Histone H3K4me3
histone acetyltransferase KAT7
COMPARTMENT: cell nucleus
MOTIF: serine-rich region {10-57}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S50}
Ser phosphorylation site {S52}
Ser phosphorylation site {S53}
Ser phosphorylation site {S56}
Ser phosphorylation site {S57}
Thr phosphorylation site {T85}
Thr phosphorylation site {T88}
Ser phosphorylation site {S99}
Ser phosphorylation site {S100}
Ser phosphorylation site {S102}
Thr phosphorylation site {T104}
Ser phosphorylation site {S124}
Thr phosphorylation site {T128}
Zn finger C2HC-type
SITE: 366-388
EFFECTOR-BOUND: Zn+2
cysteine residue {C474}
binding site
SITE: 477-477
FOR-BINDING-OF: Acetyl-CoA
Acetyl-CoA binding {482-488}
binding site
SITE: 512-512
FOR-BINDING-OF: Acetyl-CoA
protein C1orf149
MOTIF: coiled coil {11-47}
Ser phosphorylation site {S136}
PHD finger protein 15
MOTIF: Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 199-249
EFFECTOR-BOUND: Zn+2
proline-rich region
SITE: 601-732
MOTIF: proline residue (SEVERAL)
References
UniProt :accession O95251
Components
histone acetyltransferase KAT7; histone acetyltransferase binding to ORC1; lysine acetyltransferase 7; MOZ, YBF2/SAS3, SAS2 & TIP60 protein 2; MYST-2 (KAT7, HBO1, HBOa, MYST2)
inhibitor of growth protein 4; p29ING4; My036 protein (ING4)
PHD finger protein 15; protein Jade-2 (PHF15, JADE2, KIAA0239)
protein C1orf149; sarcoma antigen NY-SAR-91 (MEAF6, C1orf149)