HAUS augmin-like complex subunit 7; 26S proteasome-associated UCH37-interacting protein 1; UCHL5-interacting protein; X-linked protein STS1769 (HAUS7, UCHL5IP, UIP1)

Function: - contributes to mitotic spindle assembly, maintenance of centrosome integrity & completion of cytokinesis as part of the HAUS augmin-like complex - binds UCHL5 Structure: belongs to the HAUS7 family Compartment: - cytoplasm, cytoskeleton, centrosome, spindle - localizes to interphase centrosomes & to mitotic spindle microtubules Alternative splicing: named isoforms=3 Expression: - detected in spleen, thymus, testis, ovary, small intestine & colon - highest expression in testis & ovary Genetics: - the gene for this protein is either identical to or adjacent to that of TREX2 - most mRNAs that encode UCHL5IP alsoinclude the N-terminal part of TREX2 Note: - uncertain whether Met-1 or Met-11 is the initiator

General

phosphoprotein protein subunit

Properties

SIZE: entity length = 368 aa MW = 41 kD COMPARTMENT: cytoplasm MOTIF: Ser phosphorylation site {S26} coiled coil {213-246}

Database Correlations

OMIM 300540 UniProt Q99871 Entrez Gene 55559 Kegg hsa:55559

References

UniProt :accession Q99871