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hand & foot syndrome; palmar-plantar erythrodysesthesia; acral erythema

Etiology: - chemotherapy-induced peripheral neuropathy - cytarabine - doxorubicin - capecitabine - 5-fluorouracil - docetaxel - paclitaxel [5] - methotrexate [2] - sickle cell disease Clinical manifestations: - painful swelling of the palms of the hands & the soles of the feet - paresthesias - skin ulcers or blisters may form on the palms & soles, especially if these areas are under pressure - peeling of the skin may occur - symptoms are often more severe in the hands than the feet - loss of fingerprints has been reported [3] * images [4] Management: - hand & foot hygiene - analgesia - symptoms generally resolve within 2-4 weeks with discontinuation of chemotherapy - frozen gloves & socks for 90 minutes after undergoing treatment with paclitaxel may help control symptoms of neuropathy [5]

Related

chemotherapy-induced peripheral neuropathy (CIPN) hand-foot-&-mouth disease

General

peripheral nerve disease; peripheral neuropathy skin disease (dermatologic disorder, dermatopathy, dermatosis) syndrome

References

  1. PALMAR-PLANTAR ERYTHRODYSESTHESIA Huntsman Cancer Institute http://www.huntsmancancer.org/patientdocs/hci/drug_side_effects/handfoot.html
  2. Medical Knowledge Self Assessment Program (MKSAP) 16, 17 American College of Physicians, Philadelphia 2012, 2015
  3. Chavarri-Guerra Y, Soto-Perez-de-Celis E Images in clinical medicine. Loss of fingerprints. N Engl J Med. 2015 Apr 16;372(16):e22 PMID: 25875278 http://www.nejm.org/doi/full/10.1056/NEJMicm1409635
  4. DermNet NZ. Hand-foot syndrome (images) http://www.dermnetnz.org/reactions/hand-foot-syndrome.html
  5. Bassett M Cryotherapy May Help Prevent Neuropathy in Cancer Patients. Less CIPN in patients wearing ice-cold gloves and socks after taxane therapy. MedPage Today. October 12, 2017 https://www.medpagetoday.com/HematologyOncology/Chemotherapy/68498 - Hanai A, Ishiguro H, Sozu T et al Effects of Cryotherapy on Objective and Subjective Symptoms of Paclitaxel-Induced Neuropathy: Prospective Self-Controlled Trial. JNCI: J Natl Cancer Institute, 110(2) Feb 1 2018 Not indexed in PubMed https://academic.oup.com/jnci/article/4443215/Effects-of-Cryotherapy-on-Objective-and-Subjective