hairy & enhancer of split-related protein HELT; HES/HEY-like transcription factor (HELT)

Function: - transcriptional repressor - binds preferentially to the canonical E box sequence 5'-CACGCG-3' (putative) - self-associates - interacts with HES5 & HEY2 Structure: - belongs to the HEY family - contains 1 basic helix-loop-helix (bHLH) domain - contains 1 Orange domain Compartment: nucleus (putative) Alternative splicing: named isoforms=2

General

DNA-binding protein transcriptional silencer (transcriptional repressor)

Properties

SIZE: entity length = 327 aa MW = 36 kD COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 52-67 helix-loop-helix NAME: helix-loop-helix SITE: 63-151 FOR-BINDING-VIA: helix-loop-helix Orange {172-207} proline-rich region SITE: 217-296 MOTIF: proline residue (SEVERAL)

Database Correlations

UniProt A6NFD8 PFAM correlations Kegg hsa:3917

References

UniProt :accession A6NFD8