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hairy/enhancer-of-split related with YRPW motif-like protein (hHeyL, hairy-related transcription factor 3, hHRT3, HEYL HRT3)
Function:
- downstream effector of Notch signaling
- may be required for cardiovascular development
- transcriptional repressor
- binds preferentially to canonical E box sequence 5'-CACGTG-3'
- represses transcription by cardiac transcriptional activators GATA4 & GATA6
- self-associates
- interacts with GATA4, GATA6, HES1, HEY1 & HEY2
- interacts with HDAC1, NCOR1 & SIN3A
Structure:
- belongs to the HEY family
- contains 1 basic helix-loop-helix (bHLH) domain
- contains 1 Orange domain
Compartment: nucleus
Expression:
- induced by activation of Notch signaling pathway
General
hairy & enhancer of split (HES)
transcriptional silencer (transcriptional repressor)
Properties
SIZE: MW = 35 kD
entity length = 328 aa
COMPARTMENT: cell nucleus
MOTIF: silencer element
SITE: 42-111
MOTIF: DNA-binding motif
SITE: 44-56
helix-loop-helix
NAME: helix-loop-helix
SITE: 57-99
FOR-BINDING-VIA: helix-loop-helix
Orange {116-153}
proline-rich region
SITE: 162-309
MOTIF: proline residue (SEVERAL)
Database Correlations
UniProt Q9NQ87
References
UniProt :accession Q9NQ87