hairy/enhancer-of-split related with YRPW motif 1 (hairy & enhancer of split-related protein 1, HESR-1, cardiovascular helix-loop-helix factor 2, HES-related repressor protein 2, HERP2, HEY1, CHF2, HESR1)

Function: - DNA-binding protein - efficient DNA binding requires dimerization with another bHLH protein Structure: - contains 1 basic helix-loop-helix (bHLH) domain - contains 1 Orange domain Compartment: nucleus Expression: - expressed in somitic mesoderm, central nervous system, kidney, heart, nasal epithelium, & limbs

Properties

SIZE: MW = 33 kD entity length = 304 aa COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 50-62 helix-loop-helix NAME: helix-loop-helix SITE: 63-105 FOR-BINDING-VIA: helix-loop-helix Orange {122-158} YRPW {294-297}

Database Correlations

OMIM 602953 UniProt Q9Y5J3 PFAM correlations

References

UniProt :accession Q9Y5J3