adapter-related protein complex 4; HA4/AP4 adaptor complex

Function: - novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system Structure: - heterotetramer of: - AP4E1 (epsilon-adaptin) - AP4B1 (beta-adaptin) - AP4M1 (my-adaptin) - AP4S1 (sigma-adaptin)

Properties

COMPARTMENT: clathrin coated vesicle MOTIF: ligand-binding site SUBUNITS: AP-4 complex subunit epsilon-1 COMPARTMENT: golgi MOTIF: membrane region AP4 beta-1 COMPARTMENT: golgi MOTIF: membrane region phosphorylation site AP-4 complex subunit mu-1 COMPARTMENT: golgi MOTIF: MHD {181-453} MOTIF: Ser phosphorylation site {S342} AP-4 complex subunit sigma-1 COMPARTMENT: golgi MOTIF: membrane region

Components

adaptor-related protein complex 4 beta-1 subunit (clathrin adaptor complex 4 beta large chain, AP-4 complex subunit beta-1, beta subunit of AP-4, AP-4 adapter complex subunit beta, beta4-adaptin, (AP4B1)) AP-4 complex subunit epsilon-1; adapter-related protein complex 4 subunit epsilon-1; AP-4 adapter complex subunit epsilon; epsilon subunit of AP-4; epsilon-adaptin (AP4E1) AP-4 complex subunit mu-1; adapter-related protein complex 4 mu-1 subunit; AP-4 adapter complex mu subunit; Mu subunit of AP-4; Mu4-adaptin; mu4; Mu-adaptin-related protein 2; mu-ARP2 (AP4M1 MUARP2) AP-4 complex subunit sigma-1; adaptor-related protein complex 4 subunit sigma-1; AP-4 adaptor complex subunit sigma-1; sigma-1 subunit of AP-4; sigma4-adaptin (AP4S1)