HA3/AP3 adaptor complex

Function: 1) adaptor complex, not clathrin-associated 2) facilitates budding of vesicles from Golgi 3) role in trafficking to lysosomes Structure: heterotetramer of: - 2 large adaptins (AP3D1 & AP3B2 or AP3B1) - 1 medium adaptin (AP3M1 or AP3M2) - 1 small adaptin (AP3S1 or AP3S2) Compartment: Golgi, vesicles Expression: - AP3B2 expression is restricted to the central nervous system

Properties

COMPARTMENT: clathrin coated vesicle MOTIF: ligand-binding site SUBUNITS: delta adaptin MOTIF: membrane region AP-3 complex subunit beta-1 COMPARTMENT: cytoplasm golgi MOTIF: Ser phosphorylation site {S276} Ser phosphorylation site {S609} serine-rich region {677-802} MOTIF: serine residue (SEVERAL) mu-adaptin MOTIF: membrane region sigma adaptin MOTIF: membrane region

References

UniProt :accession Q9Y2T2, P53677

Components

AP-3 complex subunit beta-1; adapter-related protein complex 3 subunit beta-1; adaptor protein complex AP-3 beta-1 subunit; beta3A-adaptin; clathrin assembly protein complex 3 beta-1 large chain (AP3B1, ADTB3A) delta adaptin (adaptor-related protein complex, delta subunit) mu adaptin (adaptor-related protein complex, mu subunit) sigma adaptin (adaptor-related protein complex sigma subunit, small adaptin)