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H5N1 influenza vaccine; avian flu vaccine (Audenz)
Indications:
- monovalent adjuvanted vaccine for the prevention of H5N1 influenza (FDA-approved Nov 2013)
Notes:
- 1st vaccine 2006
- 12-fold higher dose than standard influenza vaccine required for protective activity
General
influenza virus vaccine, inactivated (Fluogen, Fluzone, Fluvirin, Flushield, Fluarix, Flulaval, Agriflu, Afluria, Flublok Quadrivalent, FluCelVax, Fluad, RIV4)
References
- Trenor JJ et al,
Safety and immunogenicity of an inactivated subvirion
influenza A (H5N1) vaccine
N Engl J Med 2006; 354:1343
PMID: 16571878
- Poland GA
Vaccines against avian influenza - a race against time.
N Engl J Med 2006; 354:1411
PMID: 16571885
- Bresson JL, Perronne C, Launay O, Gerdil C, Saville M, Wood J,
Hoschler K, Zambon MC.
Safety and immunogenicity of an inactivated split-virion
influenza A/Vietnam/1194/2004 (H5N1) vaccine: phase I
randomised trial.
Lancet. 2006 May 20;367(9523):1657-64.
PMID: 16714186
- FDA advisory panel backs prototype Glaxo bird flu virus
Nov 14 2012 (Reuters)
http://www.reuters.com/article/2012/11/14/glaxo-birdflu-vaccine-idUSL1E8MEJ8U20121114
- FDA News Release: Nov. 22, 2013
FDA approves first adjuvanted vaccine for prevention of H5N1
avian influenza.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm376444.htm
- Brooks M
FDA Approves Novel Pandemic Influenza Vaccine.
Medscape - Feb 03, 2020.
https://www.medscape.com/viewarticle/924729