H1 kinase/cyclin E complex

H1 kinase may associate with cyclin E.

General

molecular complex serine/threonine kinase

Properties

STATE: active state MOTIF: S/T phosphorylation site kinase domain MOTIF: ATP-binding site NAME: ATP-binding site SUBUNITS: serine/threonine protein kinase H1 COMPARTMENT: cytoplasm cell nucleus golgi endoplasmic reticulum MOTIF: myristoylation site SITE: G2 EFFECTOR-BOUND: myristate cysteine residue {C3} MODIFICATION: palmitate COMPARTMENT: membrane kinase domain SITE: 98-355 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 104-112 ATP-binding site NAME: ATP-binding site SITE: 127-127 aspartate residue {D218} binding site EFFECTOR-BOUND: cyclin E BOUND-VIA: cyclin box Ser phosphorylation site {S380} Ser phosphorylation site {S381} STATE: active state cyclin E MOTIF: ubiquitination site (destruction box, D-box) SITE: N-TERMINAL FOR-BINDING-OF: ubiquitin cyclin box EFFECTOR-BOUND: serine/threonine protein kinase H1 BOUND-VIA: binding site Tyr-phosphate

References

Dou et al BBRC 214:771 1995

Components

cyclin E serine/threonine protein kinase H1; H1 kinase; PSK-H1 (PSKH1)