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G-protein coupled receptor family C group 6 member A (hGPRC6A, G-protein coupled receptor 33, hGPCR33, GPRC6A GPCR33)
Function:
1) activated by both amino acids & extracellular Ca+2
2) linked to G-protein that activates IP3/Ca+2 second messenger system
3) extracellular calcium-sensing in osteoblasts
4) osteocalin, stimulates activity in presence of Ca+2
5) lower affinity for calcium than CASR
6) receptor for amino acids preference for basic amino acids L-Lys, L-Arg L-ornithine
7) regulatory component of the urea cycle
Structure: homodimer, disulfide-linked, N-glycosylated
Compartment: cell membrane; multi-pass membrane protein
Alternative splicing: named isoforms=3
Expression:
- expressed in brain, skeletal muscle, testis, bone, calvaria, osteoblasts, leukocytes > liver, heart, kidney, spleen > lung, pancreas, placenta, ovary.
- not expressed in thymus, prostate, small intestine, tongue, colon
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: MW = 105 kD
entity length = 926 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-18}
exoplasmic domain {19-594}
MOTIF: N-glycosylation site {N332}
N-glycosylation site {N567}
N-glycosylation site {N590}
transmembrane domain {595-615}
cytoplasmic loop {616-631}
transmembrane domain {632-652}
exoplasmic loop {653-669}
transmembrane domain {670-690}
cytoplasmic loop {691-704}
transmembrane domain {705-725}
exoplasmic loop {726-748}
MOTIF: N-glycosylation site {N733}
transmembrane domain {749-769}
cytoplasmic loop {770-782}
transmembrane domain {783-803}
exoplasmic loop {804-810}
transmembrane domain {811-831}
cytoplasmic domain {832-926}
Database Correlations
UniProt Q5T6X5
PFAM correlations
References
UniProt :accession Q5T6X5