G-protein coupled receptor 33 (GPR33)

Function: 1) orphan receptor 2) chemoattractant receptor (putative) Expression: - expressed in spleen, lung, heart, liver, kidney, pancreas, thymus, gonads, leukocytes Polymorphism: - gene inactivated in most individuals - in most individuals a nonsense mutation transforms Arg-140 into a premature stop codon. - 1166 of 1217 individuals with a stop codon in both alleles, 50 heterozygous, 1 with Arg-140 in both alleles. Pathology: - GPR33 has undergone independent pseudogenization in human, chimpanzee, orangutan, siamang & rat - selective inactivation may be due to its interaction with a putative pathogen that could use GPR33 as receptor for cell invasion

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: MW = 38 kD entity length = 333 aa COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-30} MOTIF: N-glycosylation site {N5} N-glycosylation site {N12} N-glycosylation site {N19} transmembrane domain {31-53} cytoplasmic loop {54-64} transmembrane domain {65-86} exoplasmic loop {87-103} MOTIF: cysteine residue {C101} MODIFICATION: cysteine residue {C179} transmembrane domain {104-124} cytoplasmic loop {125-143} transmembrane domain {144-165} exoplasmic loop {166-209} MOTIF: cysteine residue {C179} MODIFICATION: cysteine residue {C101} transmembrane domain {210-230} cytoplasmic loop {231-246} transmembrane domain {247-268} exoplasmic loop {269-283} MOTIF: N-glycosylation site {N272} transmembrane domain {284-303} cytoplasmic domain {304-333}

Database Correlations

OMIM 610118 UniProt Q49SQ1 Pfam PF00001

References

UniProt :accession Q49SQ1