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G-protein coupled receptor 139 (GPR139, Gq-coupled orphan receptor GPRg1, G-protein-coupled receptor PGR3, GPRG1, PGR3)
Function:
1) orphan receptor
2) linked to Gq protein-mediated pathway
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- expressed almost exclusively in the brain
- expressed at very low levels in peripheral tissues
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: MW = 41 kD
entity length = 353 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-29}
MOTIF: N-glycosylation site {N11}
transmembrane domain {30-50}
cytoplasmic loop {51-65}
transmembrane domain {66-86}
exoplasmic loop {87-102}
transmembrane domain {103-123}
cytoplasmic loop {124-148}
transmembrane domain {149-169}
exoplasmic loop {170-181}
transmembrane domain {182-202}
cytoplasmic loop {203-228}
transmembrane domain {229-249}
exoplasmic loop {250-268}
transmembrane domain {269-289}
cytoplasmic domain {290-353}
Database Correlations
UniProt Q6DWJ6
Pfam PF00001
Kegg hsa:1242
References
UniProt :accession Q6DWJ6