G-protein coupled receptor 132 (G2 accumulation protein, GPR132, G2A)

Function: 1) orphan receptor 2) activates a G-alpha protein, most likely Gq-alpha 3) apoptosis 4) functions at G2/M checkpoint to delay mitosis 5) slows proliferation 6) promotes repair of damaged DNA 7) internalized & accumulated in endosomal compartments 8) LPC triggers the relocalization from the endosomal compartment to the cell surface 9) induced by stress and DNA-damaging agents Structure: belongs to the G-protein coupled receptor 1 family Compartment: - cell membrane - internalized & accumulated in endosomal compartments - lysophosphatidylcholine triggers the relocalization from the endosomal compartment to the cell surface (putative) Alternative splicing: named isoforms=2 Expression: expressed in macrophages, spleen, thymus > heart, lung Pathology: -expressed in atherosclerotic plaques, around lipid core & at shoulder region

General

glycoprotein orphan receptor G-protein coupled receptor; serpentine receptor

Properties

SIZE: MW = 42 kD entity length = 380 aa COMPARTMENT: endosome MOTIF: exoplasmic domain {1-45} MOTIF: N-glycosylation site {N35} transmembrane domain {46-68} cytoplasmic loop {69-79} transmembrane domain {80-102} exoplasmic loop {103-116} MOTIF: cysteine residue {C115} MODIFICATION: cysteine residue {C186} transmembrane domain {117-138} cytoplasmic loop {139-158} MOTIF: arginine-rich region {151-157} MOTIF: arginine residue (SEVERAL) transmembrane domain {159-178} exoplasmic loop {179-197} MOTIF: cysteine residue {C186} MODIFICATION: cysteine residue {C115} transmembrane domain {198-220} cytoplasmic loop {221-246} transmembrane domain {247-269} exoplasmic loop {270-288} transmembrane domain {289-311} cytoplasmic domain {312-380}

Database Correlations

OMIM 606167 UniProt Q9UNW8 Pfam PF00001 Kegg hsa:2993

References

UniProt :accession Q9UNW8