P2Y purinoceptor 14; P2Y14; G-protein coupled receptor 105; UDP-glucose receptor (P2RY14, GPR105, KIAA0001)

Function: - receptor for UDP-glucose & other UDP-sugars, coupled to G-proteins - not activated by ATP, ADP, UTP or ATP Structure: - belongs to the G-protein coupled receptor 1 family Compartment: - cell membrane; multi-pass membrane protein Expression: - expression in the placenta, adipose tissue, stomach & intestine > brain, spleen, lung & heart > kidney

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 338 aa MW = 39 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-29} MOTIF: N-glycosylation site {N3} transmembrane domain {30-50} cytoplasmic loop {51-55} transmembrane domain {56-76} exoplasmic loop {77-96} MOTIF: cysteine residue {C94} MODIFICATION: cysteine residue {C172} transmembrane domain {97-117} cytoplasmic loop {118-139} transmembrane domain {140-160} exoplasmic loop {161-188} MOTIF: N-glycosylation site {N161} cysteine residue {C172} MODIFICATION: cysteine residue {C94} transmembrane domain {189-209} cytoplasmic loop {210-234} transmembrane domain {235-255} exoplasmic loop {256-278} transmembrane domain {279-299} cytoplasmic domain {300-338}

Database Correlations

OMIM 610116 UniProt Q15391 Pfam PF00001 Entrez Gene 9934 Kegg hsa:9934

References

UniProt :accession Q15391