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neuropeptide FF receptor 2; G-protein coupled receptor 74; G-protein coupled receptor HLWAR77; neuropeptide G-protein coupled receptor (NPFFR2, GPR74, NPFF2, NPGPR)
Function:
- receptor for NPAF (A-18-F-amide) & NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides
- can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands.
- mediates its action by association with G proteins that activate a phosphatidylinositol-Ca+2 second messenger system
Structure:
- belongs to the G-protein coupled receptor 1 family
Compartment:
- cell membrane; multi-pass membrane protein
Alternative splicing: named isoforms=4
Expression:
- isoform 1
a) abundant in placenta
b) highly expressed in thymus, testis, & small intestine
c) expressed at low levels in several tissues including spleen, prostate, brain, heart, ovary, colon, kidney, lung, liver & pancreas
d) not expressed in skeletal muscle & leukocytes
- isoform 2
a) expression is highest in placenta (relatively low level compared to isoform 1)
b) very low level of expression in other tissues including adipose tissue & many brain regions
- isoform 3 is expressed in brain & hear > kidney, liver, lung & pancreas
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 522 aa
MW = 60 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-147}
MOTIF: N-glycosylation site {N110}
N-glycosylation site {N122}
N-glycosylation site {N133}
transmembrane domain {148-168}
cytoplasmic loop {169-184}
transmembrane domain {185-205}
exoplasmic loop {206-221}
MOTIF: cysteine residue {C220}
MODIFICATION: cysteine residue {C308}
transmembrane domain {222-242}
cytoplasmic loop {243-262}
transmembrane domain {263-283}
exoplasmic loop {284-319}
MOTIF: N-glycosylation site {N300}
cysteine residue {C308}
MODIFICATION: cysteine residue {C220}
transmembrane domain {320-340}
cytoplasmic loop {341-377}
transmembrane domain {378-398}
exoplasmic loop {399-413}
transmembrane domain {414-434}
cytoplasmic domain {435-522}
Database Correlations
OMIM 607449
UniProt Q9Y5X5
Pfam PF00001
Entrez Gene 10886
Kegg hsa:10886
References
UniProt :accession Q9Y5X5