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G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B; niacin receptor 2; nicotinic acid receptor 2 (GPR109B, HM74B, NIACR2, HCAR3)
Function:
- receptor for 3-OH-octanoid acid
- mediates negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in fatty acid beta-oxidation rates
- acts as a low affinity receptor for nicotinic acid
- this effect requires pharmaceutical doses of nicotinic acid
Structure:
- belongs to the G-protein coupled receptor 1 family
Compartment:
- cell membrane; multi-pass membrane protein
Expression:
- expression is largely restricted to adipose tissue & spleen
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 387 aa
MW = 44 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-28}
transmembrane domain {29-50}
cytoplasmic loop {51-63}
transmembrane domain {64-85}
exoplasmic loop {86-102}
MOTIF: cysteine residue {C100}
MODIFICATION: cysteine residue {C177}
transmembrane domain {103-123}
cytoplasmic loop {124-142}
transmembrane domain {143-163}
exoplasmic loop {164-194}
MOTIF: cysteine residue {C177}
MODIFICATION: cysteine residue {C100}
transmembrane domain {195-209}
cytoplasmic loop {210-236}
transmembrane domain {237-256}
exoplasmic loop {257-273}
transmembrane domain {274-298}
cytoplasmic domain {299-387}
Database Correlations
OMIM 606039
UniProt P49019
Pfam PF00001
Entrez Gene 8843
Kegg hsa:8843
References
- UniProt :accession P49019
- SeattleSNPs
http://pga.gs.washington.edu/data/gpr109b/