G-protein coupled receptor 87; G-protein coupled receptor 95 (GPR87, GPR95, FKSG78)

Function: - receptor for lysophosphatidic acid (LPA) - necessary for TP53/p53-dependent survival in response to DNA damage Structure: - belongs to the G-protein coupled receptor 1 family Compartment: - cell membrane; multi-pass membrane protein Expression: - expressed in placenta & prostate - weaker expression in thymus - not expressed in thalamus, hippocampus, pons or cerebellum - overexpressed in squamous cell carcinoma of the lung - induced by expression of TP53 & by DNA damage (TP53-dependent)

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 358 aa MW = 41 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-47} MOTIF: N-glycosylation site {N4} N-glycosylation site {N25} N-glycosylation site {N33} transmembrane domain {48-68} cytoplasmic loop {69-75} transmembrane domain {76-96} exoplasmic loop {97-116} MOTIF: cysteine residue {C114} MODIFICATION: cysteine residue {C192} transmembrane domain {117-137} cytoplasmic loop {138-159} transmembrane domain {160-180} exoplasmic loop {181-208} MOTIF: cysteine residue {C192} MODIFICATION: cysteine residue {C114} transmembrane domain {209-229} cytoplasmic loop {230-256} transmembrane domain {257-277} exoplasmic loop {278-297} transmembrane domain {298-318} cytoplasmic domain {319-358}

Database Correlations

OMIM 606379 UniProt Q9BY21 Pfam PF00001 Entrez Gene 53836 Kegg hsa:53836