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G protein-coupled receptor GPR85 (super conserved receptor expressed in brain 2, PKrCx1)
Function:
- orphan receptor
Structure:
- belongs to the G-protein coupled receptor 1 family
Compartment:
- cell membrane; multi-pass membrane protein
Expression:
- highly expressed in brain & testis
- lower levels in small intestine, placenta & spleen
- detected in all brain regions tested
- lower levels in the corpus callosum, medulla & spinal cord
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: MW = 42 kD
entity length = 370 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-25}
MOTIF: N-glycosylation site {N3}
transmembrane domain {26-46}
cytoplasmic loop {47-57}
transmembrane domain {58-78}
exoplasmic loop {79-96}
MOTIF: N-glycosylation site {N83}
cysteine residue {C94}
MODIFICATION: cysteine residue {C172}
transmembrane domain {97-117}
cytoplasmic loop {118-137}
transmembrane domain {138-158}
exoplasmic loop {159-188}
MOTIF: cysteine residue {C172}
MODIFICATION: cysteine residue {C94}
N-glycosylation site {N182}
transmembrane domain {189-209}
cytoplasmic loop {210-286}
transmembrane domain {287-307}
exoplasmic loop {308-313}
transmembrane domain {314-334}
cytoplasmic domain {335-370}
Database Correlations
OMIM 605188
UniProt P60893
Pfam PF00001
Entrez Gene 54329
Kegg hsa:54329
References
UniProt :accession Q9NPD1