G protein-coupled receptor GPR81; FKSG80 protein (GPR81, HCAR1, FKSG80)

Function: orphan receptor Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: - expressed in pituitary tissue - not detected in frontal, temporal & occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumbens, & hippocampus

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: MW = 39 kD entity length = 346 aa COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-21} MOTIF: N-glycosylation site {N3} transmembrane domain {22-42} cytoplasmic loop {43-49} transmembrane domain {50-70} exoplasmic loop {71-89} MOTIF: cysteine residue {C88} MODIFICATION: cysteine residue {C165} transmembrane domain {90-110} cytoplasmic loop {111-130} transmembrane domain {131-151} exoplasmic loop {152-182} MOTIF: cysteine residue {C165} MODIFICATION: cysteine residue {C88} transmembrane domain {183-203} cytoplasmic loop {204-220} transmembrane domain {221-241} exoplasmic loop {242-261} transmembrane domain {262-281} cytoplasmic domain {282-346}

Database Correlations

OMIM 606923 UniProt Q9BXC0 Pfam PF00001 Kegg hsa:2719