neuropeptides B/W receptor type 2; G-protein coupled receptor 8 (NPBWR2, GPR8)

Function: - interacts specifically with a number of opioid ligands - receptor for neuropeptides B & W, which may be involved in neuroendocrine system regulation, food intake & the organization of other signals Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: - expressed in caudate nucleus, hyppocampus & amygdala > thalamus, parietal cortex, pituitary gland, adrenal gland & lymph nodes

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 333 aa MW = 37 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-45} MOTIF: N-glycosylation site {N24} N-glycosylation site {N29} N-glycosylation site {N34} transmembrane domain {46-69} cytoplasmic loop {70-80} transmembrane domain {81-105} exoplasmic loop {106-120} MOTIF: cysteine residue {C117} MODIFICATION: cysteine residue {C197} transmembrane domain {121-140} cytoplasmic loop {141-165} transmembrane domain {166-185} exoplasmic loop {186-211} MOTIF: cysteine residue {C197} MODIFICATION: cysteine residue {C117} transmembrane domain {212-233} cytoplasmic loop {234-257} transmembrane domain {258-282} exoplasmic loop {283-292} transmembrane domain {293-307} cytoplasmic domain {308-333}

Database Correlations

OMIM 600731 UniProt P48146 Pfam PF00001 Entrez Gene 2832 Kegg hsa:2832

References

UniProt :accession P48146