neuropeptides B/W receptor type 1; G-protein coupled receptor 7 (NPBWR1, GPR7)

Function: - interacts specifically with a number of opioid ligands - receptor for neuropeptides B & W, which may be involved in neuroendocrine system regulation, food intake & the organization of other signals - higher affinity for neuropeptide B Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane; multi-pass membrane protein Expression: - found in cerebellum & frontal cortex - expressed in hipppocampus, amygdala & trachea > fetal brain, pituitary gland & prostate - not expressed in caudate, accumbens, kidney or liver Pathology: detected at high levels in lung carcinoma

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 328 aa MW = 36 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-37} MOTIF: N-glycosylation site {N3} N-glycosylation site {N13} N-glycosylation site {N25} transmembrane domain {38-61} cytoplasmic loop {62-72} transmembrane domain {73-97} exoplasmic loop {98-112} MOTIF: cysteine residue {C109} MODIFICATION: cysteine residue {C188} transmembrane domain {113-132} cytoplasmic loop {133-157} transmembrane domain {158-177} exoplasmic loop {178-202} MOTIF: cysteine residue {C188} MODIFICATION: cysteine residue {C109} transmembrane domain {203-224} cytoplasmic loop {225-248} transmembrane domain {249-273} exoplasmic loop {274-283} transmembrane domain {284-298} cytoplasmic domain {299-328}

Database Correlations

OMIM 600730 UniProt P48145 Pfam PF00001 Entrez Gene 2831

References

UniProt :accession P48145