neuromedin-U receptor 1; NMU-R1; G-protein coupled receptor 66; G-protein coupled receptor FM-3 (NMUR1, GPR66)

Function: - receptor for the neuromedin-U & neuromedin-S neuropeptides (putative) Structure: - belongs to the G-protein coupled receptor 1 family Compartment: - cell membrane; multi-pass membrane protein Expression: - expressed in greatest abundance in peripheral organs, particularly in GI tract & urogenital systems - highest expression in testes - much lower expression in central nervous system - within the CNS, expressed in highest abundance in the cerebellum, dorsal root ganglia, hippocampus, & spinal cord Note: - uncertain whether Met-1 or Met-24 is the initiator

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 426 aa MW = 47 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-65} MOTIF: N-glycosylation site {N7} N-glycosylation site {N27} N-glycosylation site {N41} transmembrane domain {66-86} cytoplasmic loop {87-97} transmembrane domain {98-118} exoplasmic loop {119-138} MOTIF: cysteine residue {C134} MODIFICATION: cysteine residue {C219} transmembrane domain {139-161} cytoplasmic loop {162-181} transmembrane domain {182-202} exoplasmic loop {203-235} MOTIF: cysteine residue {C219} MODIFICATION: cysteine residue {C134} transmembrane domain {236-256} cytoplasmic loop {257-294} transmembrane domain {295-315} exoplasmic loop {316-338} transmembrane domain {339-359} cytoplasmic domain {360-426}

Database Correlations

OMIM 604153 UniProt Q9HB89 Pfam PF00001 Entrez Gene 10316 Kegg hsa:10316

References

UniProt :accession Q9HB89