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sphingosine 1-phosphate receptor GPR6; G-protein coupled receptor 6 (GPR6)
Function:
- receptor for the lysosphingolipid sphingosine 1-phosphate (S1P)
- mediates acitivity via G proteins that activate a phosphatidylinositol-Ca+2 second messenger system (putative)
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
General
glycoprotein
phosphoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 362 aa
MW = 38 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-74}
MOTIF: N-glycosylation site {N2}
N-glycosylation site {N9}
alanine-rich region {21-28}
MOTIF: alanine residue (SEVERAL)
alanine-rich region {40-43}
MOTIF: alanine residue (SEVERAL)
N-glycosylation site {N51}
transmembrane domain {75-94}
cytoplasmic loop {95-106}
transmembrane domain {107-130}
exoplasmic loop {131-142}
transmembrane domain {143-164}
cytoplasmic loop {165-185}
transmembrane domain {186-205}
exoplasmic loop {206-230}
MOTIF: cysteine residue {C216}
MODIFICATION: cysteine residue {C299}
transmembrane domain {231-249}
cytoplasmic loop {250-277}
transmembrane domain {278-304}
MOTIF: cysteine residue {C299}
MODIFICATION: cysteine residue {C216}
exoplasmic loop {305-309}
transmembrane domain {310-331}
cytoplasmic domain {332-362}
MOTIF: cysteine residue {C345}
MODIFICATION: palmitate
COMPARTMENT: membrane
Ser phosphorylation site {S356}
Ser phosphorylation site {S358}
Ser phosphorylation site {S360}
Database Correlations
OMIM 600553
UniProt P46095
Pfam PF00001
Entrez Gene 2830
Kegg hsa:2830
References
UniProt :accession P46095